Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 49, Pages 17666-17670Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201911086
Keywords
[3+2] annulation; asymmetric catalysis; C-H activation; rhodium; strained olefins
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Funding
- NSFC [21525208]
- SNNU
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C-H bond activation is mostly limited to ortho selectivity. Activation of both ortho and meta C-H bonds constitutes a particularly important strategy for annulation, but has rarely been studied in enantioselective systems. Reported herein is rhodium(III)-catalyzed asymmetric [3+2] transannulation of arenes with 7-azabenzonorbornadienes. Two distinct classes of arenes have been identified as substrates, and the coupling proceeded with high enantioselectivity and excellent diastereoselectivity through sequential activation of ortho and meta C-H bonds.
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