Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 47, Pages 16894-16898Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201910955
Keywords
fluorophores; imaging; immunology; molecular logic; tumour microenvironment
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Funding
- MSCA Individual Fellowship [704912]
- Wellcome Trust [101067/Z/13/Z]
- Wellcome-UoE Institutional Strategic Support Fund ISSF2 [615KIT/J22738]
- MRC Centre Grant [MR/N022556/1]
- ERC Consolidator Grant [771443]
- Flow Cytometry unit at UoE
- Confocal Advanced Light Microscopy unit at UoE
- MRC [MR/N022556/1] Funding Source: UKRI
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We report the novel chemical design of fluorescent activatable chemokines as highly specific functional probes for imaging subpopulations of immune cells in live tumours. Activatable chemokines behave as AND-gates since they emit only after receptor binding and intracellular activation, showing enhanced selectivity over existing agents. We have applied this strategy to produce mCCL2-MAF as the first probe for in vivo detection of metastasis-associated macrophages in a preclinical model of lung metastasis. This strategy will accelerate the preparation of new chemokine-based probes for imaging immune cell function in tumours.
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