Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 44, Pages 15767-15771Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909928
Keywords
asymmetric hydrogenation; chiral amines; cobalt; hydrazines; hydrazones
Categories
Funding
- Shanghai Municipal Education Commission [201701070002E00030]
- National Natural Science Foundation of China [21620102003, 21831005, 91856106, 21572131]
Ask authors/readers for more resources
An efficient cobalt-catalyzed asymmetric hydrogenation of C=N bonds has been realized. Chiral hydrazines were obtained in high yields and with excellent enantioselectivities (95-98 % ee). The hydrogenation went smoothly at up to 2000 substrate/catalyst and on a gram scale. The success of this reaction relies on the presence of an NHBz group in the substrates, with the reactivity and enantioselectivity improved by an assisted coordination to the cobalt atom and a nonbonding interaction with the ligand. Furthermore, this reaction has practical applications for the synthesis of several useful chiral nitrogen-containing compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available