Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 44, Pages 15824-15828Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201909855
Keywords
atroposelectivity; indoles; multicomponent reaction; organocatalysis; synthetic methods
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Funding
- National Natural Science Foundation of China [21572200]
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An efficient organocatalytic atroposelective three-component cascade reaction of 2,3-diketoesters, aromatic amines, and 1,3-cyclohexanediones has been developed for the highly enantioselective synthesis of axially chiral N-arylindoles. The success of this method derives from the use of a newly developed second-generation chiral spirocyclic phosphoric acid as the catalyst. In addition, this protocol was extended to the synthesis of an axially chiral monophosphorus ligand.
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