Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 3, Pages 1243-1247Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201911537
Keywords
annulation; asymmetric catalysis; heterocycle; palladium
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Funding
- Tamaki Foundation
- National Science Foundation [ECCS-1542152]
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A novel Pd-0-catalyzed asymmetric [4+3] annulation reaction of two readily accessible starting materials has been developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo-, and enantioselectivtities, leading to valuable tetrahydroazepines and benzo[b]oxepines.
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