Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 47, Pages 16943-16951Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201907880
Keywords
hydrogels; regenerative medicine; self-assembling peptides; solid-state NMR; tissue engineering
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Funding
- Netherlands Science Organisation for Scientific Research (NWO) [723.014.003, 711.018.001]
- Ricerca Corrente fund - Italian Ministry of Health
- uNMR-NL, an NWO [184.032.207]
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Stem-cell behavior is regulated by the material properties of the surrounding extracellular matrix, which has important implications for the design of tissue-engineering scaffolds. However, our understanding of the material properties of stem-cell scaffolds is limited to nanoscopic-to-macroscopic length scales. Herein, a solid-state NMR approach is presented that provides atomic-scale information on complex stem-cell substrates at near physiological conditions and at natural isotope abundance. Using self-assembled peptidic scaffolds designed for nervous-tissue regeneration, we show at atomic scale how scaffold-assembly degree, mechanics, and homogeneity correlate with favorable stem cell behavior. Integration of solid-state NMR data with molecular dynamics simulations reveals a highly ordered fibrillar structure as the most favorable stem-cell scaffold. This could improve the design of tissue-engineering scaffolds and other self-assembled biomaterials.
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