Journal
ANALYTICAL SCIENCES
Volume 35, Issue 10, Pages 1155-1159Publisher
JAPAN SOC ANALYTICAL CHEMISTRY
DOI: 10.2116/analsci.19N018
Keywords
Nitrogen-containing compounds; ESI-MS; mouth-exhaled breath; nose-exhaled breath
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Funding
- Key Program of 13th five-year plan, CASHIPS [KP-2017-25]
- Provincial Natural Foundation of Anhui Province [1808085MF169]
- Natural Science Research Project of Anhui Universities [KJ2018A0086]
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Nitrogen-containing compounds are important components in human breath. However, their origins have not yet been clearly understood. In this study, a modified electrospray ionization (ESI) source coupling with quadrupole time-of-flight mass spectrometry has been used for breath analysis. Fourteen nitrogen-containing compounds were identified in mouth-exhaled breath, and 10 of them were from the oral cavity and oropharynx. Moreover, 8 of these nitrogen-containing compounds were recognized as endogenous metabolites. This result provides important clues for exploring the biological origins of these nitrogen-containing compounds. Observation of the ion suppression phenomenon also indicates that breath analysis should be carried out after clearing of the oral cavity and oropharynx, or directly through nose-breathing to eliminate the influence of those nitrogen-containing compounds from the oral cavity.
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