Journal
BIOCONJUGATE CHEMISTRY
Volume 27, Issue 8, Pages 1796-1801Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.6b00275
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Funding
- HHMI International Student Research Fellowship
- Villum Kann Rasmussens Foundation
- Laboratory Directed Research and Development Program at Lawrence Berkeley National Laboratories
- Berkeley Chemical Biology Graduate Program (NIH) [1 T32 GM066698]
- Department of Defense through the National Defense Science and Engineering Graduate Fellowship
- U.S. Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division [DE-AC02-05CH11231]
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We have synthesized targeted, selective, and highly sensitive Xe-129 NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyper polarized Xe-129 NMR signal contrast and hyper-CEST Xe-129 MM image contrast indicated its promise as highly sensitive hyperpolarized Xe-129 NMR nanoscale biosensor for future applications in cancer detection in vivo.
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