Journal
ANALYTICA CHIMICA ACTA
Volume 1096, Issue -, Pages 26-33Publisher
ELSEVIER
DOI: 10.1016/j.aca.2019.10.048
Keywords
ZnFe2O4; Dopamine; Electrochemical detection; Biosensor
Categories
Funding
- National Natural Science Foundation of China [21305025, 51571072, 51871078, 81771508]
- Heilongjiang Science Foundation [E2018028]
- Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education [2017001, 2017002]
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Accurate and sensitive detection of dopamine (DA) is fundamental to monitor and diagnose certain neurological diseases. Herein, highly ordered mesoporous ZnFe2O4 (OM-ZnFe2O4) is prepared via a facile nanocasting method and shows the highly sensitive in the electrochemical detection of DA. The optimized OM-ZnFe2O4-40 shows the most excellent activity for DA oxidation in a wide linear range from 2 to 600 nM with a quick response time of 5 s, high sensitivity of 0.094 nA nM(-1) and a lower detection limit of 0.4 nM (S/N = 3). The electrode modified with OM-ZnFe2O4 is further successfully used to monitor the increase of DA concentration induced by K+-stimulation of living PC12 cells in a neurological environment. This work offers a simple and powerful strategy for designing electrodes for detecting DA in biological systems. (C) 2019 Elsevier B.V. All rights reserved.
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