Journal
ANALYTICA CHIMICA ACTA
Volume 1100, Issue -, Pages 191-199Publisher
ELSEVIER
DOI: 10.1016/j.aca.2019.11.008
Keywords
Nitrogen-doped porous graphene; Graphene quantum dots; Ascorbic acid; CoOOH nanosheets; In vivo
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Funding
- Natural Science Foundation of China [21804319, 21776302, 21776308]
- Science Foundation of China University of Petroleum (Beijing) [2462016YJRC027, 2462017BJB04, 2462015YQ0306]
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Herein, we employ 3D nitrogen-doped porous graphene frameworks (NPG) as raw material to prepare emissive nitrogen doped graphene quantum dots (r-NGQDs) via chemical oxidation method. The asprepared fluorescent r-NGQDs was integrated with CoOOH nanosheets to construct a sensing platform for in vivo ascorbic acid (AA) analysis. Initially, the fluorescence emission intensity of r-NGQDs was quenched by CoOOH nanosheets based on the inner filter effect (IFE). Then the quenched intensity of rNGQDs and CoOOH nanosheets system was enlightened by addition of AA, since AA could consume CoOOH nanosheets through redox reaction, leading to the release of r-NGQDs and fluorescence restoration. Moreover, the restored fluorescence intensity of r-NGQDs is highly dependent on the concentration of AA which endows them as a quantitative analysis of AAwith a limit of detection (LOD) reach up to 1.85 mu M (n = 3) in aqueous solution. Finally, the as constructed bionanosensor was further employed for in vivo analysis of AA in living rat brain microdialysate with basal value up to 9.4 +/- 1.4 mM (n = 3). (C) 2019 Elsevier B.V. All rights reserved.
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