Journal
ANALYTICA CHIMICA ACTA
Volume 1079, Issue -, Pages 164-170Publisher
ELSEVIER
DOI: 10.1016/j.aca.2019.06.042
Keywords
Fluorescence; Metal-organic frameworks; Nanosheets; H2O2; Glucose
Categories
Funding
- National Natural Science Foundation of China (NSFC) [21505076]
- Young Elite Scholar Support (YESS) Program from CAST
- Program of Jiangsu Specially-Appointed Professor
- NSF of Jiangsu Province of China
- Innovation Team Program of Jiangsu Province of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Ultrathin two-dimensional (2D) metal-organic framework (MOF) nanosheets have attracted numerous attention due to their unparalleled advantages such as unique structures, large surface areas, good stability and high catalytic efficiency. In this paper, 2D Cu(bpy)(2)(OTf)(2) nanosheets (Cu-MOF, bpy = 4,4-bipyridine, OTf = trifluoromethanesulfonate) are first utilized to achieve the fluorescent detection for H2O2 and glucose with their intrinsic peroxidase-like activity. The fluorescent biosensor Cu-MOF nanosheets were achieved by the efficient catalysis of non-fluorescent thiamine (TH) to strong fluorescent thiochrome in the presence of H2O2. With the combination of glucose oxidase, highly selective and sensitive fluorescent detection for glucose could be established with a detection limit of 0.41 mu M and two separate linear ranges of 10-100 mu M and 100-1000 mu M, respectively. Furthermore, the developed method has been applied to human serum for the quantitative determination of glucose as a clinical diagnosis indicator of diabetes mellitus. (C) 2019 Elsevier B.V. All rights reserved.
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