Journal
BIOCONJUGATE CHEMISTRY
Volume 27, Issue 3, Pages 569-575Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.5b00590
Keywords
-
Categories
Funding
- French National Agency (ANR) [ANR-10-LABX-57]
- SVE5 program
Ask authors/readers for more resources
Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available