Journal
BIOCHIP JOURNAL
Volume 11, Issue 1, Pages 46-56Publisher
KOREAN BIOCHIP SOCIETY-KBCS
DOI: 10.1007/s13206-016-1107-6
Keywords
Glucose detection; Graphene oxide; Silica coating; SERS; Signal enhancement
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2016-A002-0048]
- Bio & Medical Technology Development Program of the National Research Foundation (NRF)
- Korean government (MSIPMOHW) [2016-A423-0045]
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In this work, 4-mercaptophenyl boronic acid (4-MPBA) was self-assembled on the surface of silver nanoparticle-embedded silica-coated graphene oxide (GO@SiOz@Ag NPs@MPBA) to detect glucose by surface enhanced Raman scattering (SERS). The SERS intensity of 4-MPBA on the GO@SiO2@Ag NPs was 2.2-fold greater than that of GO@Ag NPs. Moreover, silica-coated GO exhibited lower background signals compared to GO. The SERS intensity of GO@SiO2@Ag NPs@MPBA peaked at 1 mM 4-MPBA. pH-dependent behavior of 4-MPBA on the GO@SiO2@Ag NPs was investigated; the highest SERS signal intensity was detected at pH 3. The binding of glucose to 4-MPBA-incorporated GO@SiO2@Ag NPs increased the SERS signals at both 1,072 and 1,588 cm(-1). The linear range was estimated from 2 to 20 mM glucose. These results provide insight into detection of glucose and the development of SERS-based biosensors using graphene oxide.
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