Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1864, Issue 5, Pages 453-470Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2016.01.012
Keywords
Fe(II)/alpha-ketoglutarate-dependent dioxygenase; C-H bond activation; Natural product; Biosynthesis; Enzymatic reaction; Engineering
Categories
Funding
- National Natural Science Foundation of China [31330003, 81373307]
- Science and Technology Commission of Shanghai Municipality [14XD1404500]
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Apart from its vital role as the terminal electron acceptor in oxidative phosphorylation in nature, dioxygen also serves as a universal agent which diversifies natural products by oxidative transformations. Ferrous iron and alpha-ketoglutarate (alpha KG)-dependent dioxygenases (alpha KGDs) are versatile enzymes that use dioxygen as an oxidant to catalyse various reactions via C-H bond activation, including hydroxylation, dealkylation, desaturation, epoxidation, epimerisation, halogenation, cyclisation, peroxide formation, and ring expansion/contraction reactions. This review updates the reported alpha KGDs that catalyse reactions related to microbial natural product biosynthesis in the past 10 years. We hope that the versatility of alpha KGDs shown here can serve as an inspiration for future engineering and catalyst design, which could provide alternative methods to meet the on-going demand for fine chemicals and pharmaceutics. (c) 2016 Elsevier B.V. All rights reserved.
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