Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1863, Issue 5, Pages 881-891Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2015.09.026
Keywords
Mammalian peroxisomes; de novo biogenesis; Growth and division; Endoplasmic reticulum; Mitochondria; Peroxisomal membrane protein
Categories
Funding
- Natural Sciences and Engineering Council
- Canadian Institutes of Health Research
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Peroxisomes are dynamic organelles that can adjust their size and number in response to cellular demand and environmental stimuli. They can propagate from pre-existing peroxisomes through growth and division, as well as de novo from the endoplasmic reticulum (ER). However, to what extend that these two distinct peroxisome biogenesis pathways are involved in maintaining peroxisome numbers in cycling cells is unclear. Recent studies in yeast suggest that the ER plays a direct role in the maintenance of peroxisomes. However, the role of the ER in mammalian system is under debate. In this review, we outline the recent progress in understanding the biogenesis of mammalian peroxisomes. We herein discuss some of the discrepancies in the literature and the outstanding questions in the field. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. (C) 2015 Elsevier B.V. All rights reserved.
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