Journal
ALZHEIMERS & DEMENTIA
Volume 16, Issue 3, Pages 561-571Publisher
WILEY
DOI: 10.1016/j.jalz.2019.09.079
Keywords
Alzheimer's disease; Autopsy; Braak tangle stage; flortaucipir; PET; Tau
Categories
Funding
- NIH [P50AG016574, R01NS89757, R01NS089544, R01DC10367, R01AG011378, R01AG041851, R01 AG034676, R01AG054449, R01NS097495, U01AG006786, R21NS094489]
- Robert Wood Johnson Foundation
- Mayo Foundation for Medical Education and Research
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Introduction: Comparison of tau (flortaucipir) positron emission tomography (FTPPET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Methods: Autopsies were performed on 26 participantswho had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTPPET signal. Results: Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P <= .02). Discussion: Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal.
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