Journal
ALZHEIMERS & DEMENTIA
Volume 15, Issue 11, Pages 1437-1447Publisher
WILEY
DOI: 10.1016/j.jalz.2019.07.009
Keywords
Neurofilament light chain; Neurogranin; Total-tau; Cerebrospinal fluid; Community-based population; Neurodegeneration; Vascular factors
Categories
Funding
- National institutes of Health/National Institute on Aging [U01 AG006786, R01 AG011378, R01 AG041851, R01 AG049704, R01 AG034676]
- GHR Foundation
- Swedish Research Council [2015-02830]
- European Research Council [681712]
- Knut and Alice Wallenberg Foundation
- Frimurarestiftelsen
- Olav Thon Foundation
- Swedish State Support for Clinical Research (ALF Vastra Gotalandsregionen)
- Swedish Government [ALFGBG-813921, ALFGBG-65930, ALFGBG-716681, ALFGBG-771071]
- Torsten Soderberg Foundation
- Swedish Alzheimer Foundation
- Hjarnfonden Sweden
- Stiftelsen Demensfonden
- Stiftelsen Hjalmar Svenssons Forskningsfond
- Stiftelsen Wilhelm och Martina Lundgrens Vetenskapsfond
- ALF-agreement [ALFGBG-813921, ALFGBG-65930, ALFGBG-716681, ALFGBG-771071]
- Swedish Research Council [2015-02830] Funding Source: Swedish Research Council
Ask authors/readers for more resources
Introduction: Three cerebrospinal fluid (CSF) markers of neurodegeneration (N) (neurofilament light [NfL], total-tau [T-tau], and neurogranin [Ng]) have been proposed under the AT(N) scheme of the National Institute on Aging-Alzheimer's Association Research Framework. Methods: We examined, in a community-based population (N = 777, aged 50-95) (1) what variables were associated with each of the CSF (N) markers, and (2) whether the variables associated with each marker differed by increased brain amyloid. CSF T-tau was measured with an automated electrochemiluminescence Elecsys immunoassay; NfL and Ng were measured with in-house enzyme-linked immunosorbent assays. Results: Multiple variables were differentially associated with CSF NfL and T-tau levels, but not Ng. Most associations were attenuated after adjustment for age and sex. T-tau had the strongest association with cognition in the presence of amyloidosis, followed by Ng. Variables associations with NfL did not differ by amyloid status. Discussion: Understanding factors that influence CSF (N) markers will assist in the interpretation and utility of these markers in clinical practice. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available