Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1863, Issue 10, Pages 2457-2464Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2016.03.006
Keywords
Mitochondrial Calcium Uniporter; Mitochondrial calcium uptake; Cardiac muscle; Skeletal muscle
Categories
Funding
- European Union (ERC mitoCalcium) [294777]
- Italian Ministries of Health
- Italian Ministries of Education, University and Research [RBFR10EGVP_002]
- NIH [1P01AG025532-01A1]
- Cariparo Foundation
- French Muscular Dystrophy Association [18857]
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Mitochondrial Ca2+ uptake regulates a wide array of cell functions, from stimulation of aerobic metabolism and ATP production in physiological settings, to induction of cell death in pathological conditions. The molecular identity of the Mitochondrial Calcium Uniporter (MCU), the highly selective channel responsible for Ca2+ entry through the IMM, has been described less than five years ago. Since then, research has been conducted to clarify the modulation of its activity, which relies on the dynamic interaction with regulatory proteins, and its contribution to the pathophysiology of organs and tissues. Particular attention has been placed on characterizing the role of MCU in cardiac and skeletal muscles. In this review we summarize the molecular structure and regulation of the MCU complex in addition to its pathophysiological role, with particular attention to striated muscle tissues. This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou. (C) 2016 The Authors. Published by Elsevier B.V.
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