Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1863, Issue 12, Pages 3125-3147Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2016.09.023
Keywords
Exosome; Xm1; Decapping; Uridylation; mRNA decay; ncRNA
Categories
Funding
- National Science Centre (NCN Maestro) [UMO-2011/02/A/NZ1/00001]
- National Centre for Research and Development (NCBR) [LIDER/35/46/L-3/11/NCBR/2012]
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RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work conducted over the last decades has defined the major mRNA decay pathways, as well as enzymes and their cofactors responsible for these processes. In contrast, our knowledge of the mechanisms of degradation of non-protein coding RNA species is more fragmentary. This review is focused on the cytoplasmic pathways of mRNA and ncRNA degradation in eu-karyotes. The major 3' to 5' and 5' to 3' mRNA decay pathways are described with emphasis on the mechanisms of their activation by the deprotection of RNA ends. More recently discovered 3'-end modifications such as uridylation, and their relevance to cytoplasmic mRNA decay in various model organisms, are also discussed. Finally, we provide up-to-date findings concerning various pathways of non-coding RNA decay in the cytoplasm. (C) 2016 Elsevier B.V. All rights reserved.
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