Journal
AGING-US
Volume 11, Issue 19, Pages 8204-8216Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.102313
Keywords
long-noncoding RNA; epithelial ovarian carcinoma; galectin-1; chemoresistance
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Funding
- National Natural Science Foundation of China [81702868, 81602703]
- Outstanding Clinical Discipline Project of Shanghai Pudong [PWYgy2018-02]
- Jiangxi Province Science Foundation for Youths [20171BAB215036]
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Recently, an increasing number of studies have reported that dysregulation of long noncoding RNAs (lncRNAs) plays an important role in cancer initiation and progression, including in epithelial ovarian carcinoma (EOC). However, little is known about the detailed biological functions of the lncRNA small nucleolar RNA host gene 22 (SNHG22) during the progression of EOC. Here, we found that SNHG22 was significantly increased in EOC tissues and was significantly associated with a low level of differentiation. Forced SNHG22 expression promoted chemotherapy resistance in EOC cells. Knockdown of SNHG22 expression increased the sensitivity of EOC cells to cisplatin and paclitaxel. Importantly, we found that SNHG22 could directly interact with miR-2467 and lead to the release of miR-2467-targeted Gal-1 mRNA. Moreover, SNHG22 overexpression induced EOC cell resistance to chemotherapy agents via PI3K/AKT and ERK cascade activation. In summary, our findings demonstrate that SNHG22 plays a critical role in the chemotherapy resistance of EOC by mediating the miR-2467/Gal-1 regulatory axis.
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