Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 1, Pages 224-229Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901321
Keywords
Spirocyclization; DABSO; Sulfur dioxide; Sulfones; diazonium salts
Categories
Funding
- Department of Science and Technology, India [DST/TMD/SERI/S111(G)]
- SK would like DST India
- UGC India
Ask authors/readers for more resources
Herein, we report an efficient synthesis of azaspiro[4,5]-decanes and azaspiro[4,5]-trienones by the radical cascade spirocyclization of N-benzylacrylamides or N-arylpropiolamides respectively. These reactions proceed under metal free conditions and involve in situ generation of aryl sulfonyl radicals from DABSO and aryl diazonium salts. Furthermore, a catalyst free visible light mediated protocol was developed for the sulfonylative spirocyclization of N-aryl alkynamides using diaryliodonium salts. The utility of these protocols were justified by the excellent compatability of a wide range of functional groups, good yields and scalablity under mild conditions at room temperature.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available