Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 362, Issue 2, Pages 320-325Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201901187
Keywords
C-O cross-coupling; telescoping; hypervalent iodine; diaryliodonium; diaryl ether
Categories
Funding
- Portland State University
Ask authors/readers for more resources
Herein, we describe a synthetic approach for arylation that exploits the in situ formation and reaction of an unsymmetrical diaryliodonium salt. In this way, aryl iodides are used as reagents in a metal-free reaction with phenols, and a trimethoxyphenyl (TMP) group is used as a dummy group to facilitate transfer of a wide range of aryl moieties. The scope of aryl electrophiles and phenol nucleophiles is broad (>30 examples) and the yields are high (52-95%, 80% avg.). One-pot coupling reactions avoid the synthesis of diaryliodonium salts and provide opportunities for sequential reactions and novel chemoselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available