Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 361, Issue 22, Pages 5182-5190Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900994
Keywords
chromeno[2; 3-b]pyridines; indole; multi-component reaction; visible light; ethyl lactate; green synthesis
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A visible light-initiated pseudo four-component reaction of salicylaldehydes, indole and malononitrile in aqueous ethyl lactate is described. This pot, atomic and step economic (PASE) methodology provides a practical approach for the preparation of various 5-substituted indole chromeno[2,3-b]pyridines from readily available starting materials at ambient temperature without any catalyst. High yields and excellent functional groups tolerance are observed.
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