Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 361, Issue 22, Pages 5140-5143Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900871
Keywords
Biocatalysis; Enzymes; Amino acids; Dynamic kinetic resolution
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We report a practical enzymatic approach for the stereoselective synthesis of hydroxylated cyclic amino acids. Using ketoreductases, cyclic ketoesters are converted with high diastereo- and enantioselectivity to all isomers of 3-hydroxyproline and 3-hydroxypipecolic acid via a dynamic kinetic reduction reaction. This work highlights the ability of enzymes to provide solutions to challenges in stereoselective synthesis.
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