Journal
ADVANCED MATERIALS
Volume 31, Issue 52, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201904914
Keywords
aggregation-induced emission; cancer immunotherapy; immunogenic cell death inducer; mitochondrial targeting; photosensitizers
Categories
Funding
- NSFC [51622305, 51873092]
- National Basic Research Program of China [2015CB856503]
- Fundamental Research Funds for the Central Universities, Nankai University [63191521, 63171218, 63191176]
- Fundamental Research Funds for the Central Universities, Nankai University, the Science and Technology Support Program of Tianjin [16YFZCSY01020]
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Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer-based ones can hardly induce sufficient ICD to achieve satisfactory cancer immunotherapy by themselves. Herein, an organic photosensitizer (named TPE-DPA-TCyP) with a twisted molecular structure, strong aggregation-induced emission activity, and specific ability is reported for effectively inducing focused mitochondrial oxidative stress of cancer cells, which can serve as a much superior ICD inducer to the popularly used ones, including chlorin e6 (Ce6), pheophorbide A, and oxaliplatin. Furthermore, more effective in vivo ICD immunogenicity of TPE-DPA-TCyP than Ce6 is also demonstrated using a prophylactic tumor vaccination model. The underlying mechanism of the effectiveness and robustness of TPE-DPA-TCyP in inducing antitumor immunity and immune-memory effect in vivo is verified by immune cell analyses. This study thus reveals that inducing focused mitochondrial oxidative stress is a highly effective strategy to evoke abundant and large-scale ICD.
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