Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1862, Issue 3, Pages 483-491Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2015.11.014
Keywords
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Funding
- Swedish Medical Research Council [11548, 20116]
- AFA Research Foundation
- ALF Goteborg [11392, 142821]
- Sten A. Olsson Foundation for Research and Culture
- Hjarnfonden
- Hagstromer's Foundation Millennium
- Swedish Stroke Foundation
- Amlov's Foundation
- NanoNet COST Action
- EU FP 7 Program EduGlia [237956]
- Torsten Soderberg's Foundation [M169/14]
- EU FP 7 Program TargetBraIn [279017]
- [BM1002]
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Astrocytes maintain the homeostasis of the central nervous system (CNS) by e.g. recycling of neurotransmitters and providing nutrients to neurons. Astrocytes function also as key regulators of synaptic plasticity and adult neurogenesis. Any insult to the CNS tissue triggers a range of molecular, morphological and functional changes of astrocytes jointly called reactive (astro)gliosis. Reactive (astro)gliosis is highly heterogeneous and also context-dependent process that aims at the restoration of homeostasis and limits tissue damage. However, under some circumstances, dysfunctional (astro)gliosis can become detrimental and inhibit adaptive neural plasticity mechanisms needed for functional recovery. Understanding the multifaceted and context-specific functions of astrocytes will contribute to the development of novel therapeutic strategies that, when applied at the right time-point, will improve the outcome of diverse neurological disorders. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. (C) 2015 Elsevier B.V. All rights reserved.
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