Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 50, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201905697
Keywords
antibacterial activity; antibacterial mechanism; hydrogen releasing materials; synergistic hydrogen-photothermal therapy; wound healing
Categories
Funding
- Natural Science Foundation of China [31900953]
- Natural Science Foundation of Guangdong Province [2018A030313462, 2017A030310297, 2017A030310471, 2018A030310644]
- Guangzhou basic and applied basic research project
- Pearl River talent program of Guangdong Province [2017GC010330]
- National Natural Science Foundation of China [51573071, 31870943, 51872188]
- Shenzhen Basic Research Program [JCYJ20170818141810756, GJHZ2018041190532315]
- Shenzhen Peacock Plan [KQTD2016053112051497]
- Natural Science Foundation of SZU [827-000143]
- Special Funds for the Development of Strategic Emerging Industries in Shenzhen [20180309154519685]
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For decades, hydrogen (H-2) gas has been recognized as an excellent antioxidant molecule that holds promise in treating many diseases like Alzheimer's, stroke, cancer, and so on. For the first time, active hydrogen is demonstrated to be highly efficient in antibacterial, antibiofilm, and wound-healing applications, in particular when used in combination with the photothermal effect. As a proof of concept, a biocompatible hydrogen-releasing PdH nanohydride, displaying on-demand controlled active hydrogen release property under near-infrared laser irradiation, is fabricated by incorporating H-2 into Pd nanocubes. The obtained PdH nanohydride combines both merits of bioactive hydrogen and photothermal effect of Pd, exhibiting excellent in vitro and in vivo antibacterial activities due to its synergistic hydrogen-photothermal therapeutic effect. Interestingly, combinational hydrogen-photothermal treatment is also proved to be an excellent therapeutic methodology in healing rats' wound with serious bacterial infection. Moreover, an in-depth antibacterial mechanism study reveals that two potential pathways are involved in the synergistic hydrogen-photothermal antibacterial effect. One is to upregulate bacterial metabolism relevant genes like dmpI, narJ, and nark, which subsequently encode more expression of oxidative metabolic enzymes to generate substantial reactive oxygen species to induce DNA damage and another is to cause severe bacterial membrane damage to release intracellular compounds like DNA.
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