Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 30, Issue 4, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201907954
Keywords
chemodynamic therapy; GSH depletion; nanozyme; PtCu3 nanocages; sonodynamic therapy
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Funding
- National Science Foundation of China [81771978, 81627901, 81773653, 51525203]
- National Basic Research Program of China [2015CB931802, 2016YFA0201200, 2018YFA0208903]
- Collaborative Innovation Center of Suzhou Nano Science and Technology, a Jiangsu Natural Science Fund for Distinguished Young Scholars [BK20170063]
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The ultrahigh concentration of glutathione (GSH) inside tumors destroys reactive oxygen species (ROS)-based therapy, improving the outcome of chemodynamic therapy (CDT)-enhanced sonodynamic therapy (SDT) by depleting GSH is full of great challenge. Herein, PtCu3 nanocages are first reported as acting as a sonosensitizer with highly efficient ROS generation under ultrasound irradiation. In addition, PtCu3 nanocages can act as horseradish peroxidase-like nanozymes, catalyzing the decomposition of H2O2 into (OH)-O-center dot under acidic conditions for CDT. Surprisingly, PtCu3 nanocages can act as another kind of nanozyme, mimicking glutathione peroxidase (GSH-Px), which plays an important role in accelerating GSH depletion by oxidizing molecules, further weakening the capacity of tumor cells scavenging ROS by GSH. Both in vitro and in vivo studies demonstrate that PtCu3 nanocages perform well in reducing GSH level for CDT-enhanced SDT. Moreover, utilizing the high absorption in the near-infrared region and strong X-ray attenuation ability, the PtCu3 nanocages are able to conduct photoacoustic/computed tomography dual-modal imaging-guided combined cancer therapy. It is worth mentioning that PtCu3 nanocages cause minimal toxicity to normal tissues at therapeutic doses. This work highlights the use of PtCu3 nanocages for effective CDT-enhanced SDT via GSH depletion.
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