Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1862, Issue 12, Pages 2232-2243Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2016.08.012
Keywords
Cardiac hypertrophy; Protein O-GlcNAcylation; Cardiac disease; Diabetes; Glucose
Funding
- Fund for Scientific Research in Industry and Agriculture (FRIA), Belgium
- Fonds de Recherche Clinique from Universite catholique de Louvain (UCL), Belgium
- Fonds National de la Recherche Scientifique et Medicale, Belgium [T.0105.14]
- Action de Recherche Concertee, UCL, Belgium
- AstraZeneca, Belgium
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O-linked attachment of the monosaccharide beta-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine residues, which is evolving as an important mechanism for the regulation of various cellular processes. The present review will, first, provide a general background on the molecular regulation of protein O-GlcNAcylation and will summarize the role of this post-translational modification in various acute cardiac pathologies including ischemia-reperfusion. Then, we will focus on research studies examining protein O-GlcNAcylation in the context of cardiac hypertrophy. A particular emphasis will be laid on the convergent but also divergent actions of O-GlcNAcylation according to the type of hypertrophy investigated, including physiological, pressure overload-induced and diabetes-linked cardiac hypertrophy. In an attempt to distinguish whether O-GlcNAcylation is detrimental or beneficial, this review will present the different O-GlcNAcylated targets involved in hypertrophy development. We will finally argue on potential interest to target O-GlcNAc processes to treat cardiac hypertrophy. This article is part of a Special Issue entitled: The role of post translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz. (C) 2016 Elsevier B.V. All rights reserved.
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