Journal
ACS NANO
Volume 13, Issue 12, Pages 13965-13984Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b05766
Keywords
multidrug-resistant bacteria; selenium nanosystem; red blood cell membrane; bacteria-responsive; biomimetic
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Funding
- National Natural Science Foundation of China [21877051, 81803027, 21701034]
- Natural Science Foundation of Guangdong Province [2018A030310628]
- Planned Item of Science and Technology of Guangdong Province [2016A020217011]
- Projects of Special Innovative of Department of Education of Guangdong Province [2017KTSCX078]
- Project of Young Innovative Talents in Universities and Colleges of Department of Education of Guangdong Province [2018KQNCX100]
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Multidrug-resistant (MDR) bacterial infections are a severe threat to public health owing to their high risk of fatality. Noticeably, the premature degradation and undeveloped imaging ability of antibiotics still remain challenging. Herein, a selenium nanosystem in response to a bacteria-infected microenvironment is proposed as an antibiotic substitute to detect and inhibit methicillin-resistant Staphylococcus aureus (MRSA) with a combined strategy. Using natural red blood cell membrane (RBCM) and bacteria-responsive gelatin nanoparticles (GNPs), the Ru-Se@GNP-RBCM nanosystem was constructed for effective delivery of Ru-complex-modified selenium nano particles (Ru-Se NPs). Taking advantage of natural RBCM, the immune system clearance was reduced and exotoxins were neutralized efficiently. GNPs could be degraded by gelatinase in pathogen-infected areas in situ; therefore, Ru-Se NPs were released to destroy the bacteria cells. Ru-Se NPs with intense fluorescence imaging capability could accurately monitor the infection treatment process. Moreover, excellent in vivo bacteria elimination and a facilitated wound healing process were confirmed by two kinds of MRSA-infected mice models. Overall, the above advantages proved that the prepared nanosystem is a promising antibiotic alternative to combat the ever-threatening multidrug-resistant bacteria.
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