Journal
ACS NANO
Volume 13, Issue 11, Pages 12901-12911Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b05383
Keywords
conjugated oligomer; nanoparticle; photothermal conversion efficiency; biodegradability; photothermal therapy
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Funding
- City University of Hong Kong (CityU Internal Funds for External Grant Schemes Project) [9678157]
- City University of Hong Kong (CityU Applied Research Grant) [9667160]
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We developed a biodegradable photothermal therapeutic (PTT) agent, pi-conjugated oligomer nanoparticles (F8 -PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent nearinfrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8 -PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both in vitro and in vivo. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.
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