Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1861, Issue 10, Pages 1513-1524Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2016.02.016
Keywords
Heart; Cardiomyopathy; Lipids; Lipotoxicity; Obesity; Diabetes
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2014-04454]
- Banting Research Foundation
- New Brunswick Health Research Foundation (NBHRF)
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The heart balances uptake, metabolism and oxidation of fatty acids (FAs) to maintain ATP production, membrane biosynthesis and lipid signaling. Under conditions where FA uptake outpaces FA oxidation and FA sequestration as triacylglycerols in lipid droplets, toxic FA metabolites such as ceramides, diacylglycerols, long-chain acyl-CoAs, and acylcarnitines can accumulate in cardiomyocytes and cause cardiomyopathy. Moreover, studies using mutant mice have shown that dysregulation of enzymes involved in triacylglycerol, phospholipid, and sphingolipid metabolism in the heart can lead to the excess deposition of toxic lipid species that adversely affect cardiomyocyte function. This review summarizes our current understanding of lipid uptake, metabolism and signaling pathways that have been implicated in the development of lipotoxic cardiomyopathy under conditions including obesity, diabetes, aging, and myocardial ischemia-reperfusion. This article is part of a Special Issue entitled: Heart Lipid Metabolism edited by G.D. Lopaschuk. (C) 2016 Elsevier B.V. All rights reserved.
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