Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 49, Pages 45467-45478Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b16962
Keywords
tumor theranostics; photothermal therapy; drug delivery; metal chalcogenides; all-in-one
Funding
- National Natural Science Foundation of China [21978165, 31701032]
- Science and Technology Commission of Shanghai Municipality [15430501200]
- Shanghai Municipal Education for foreign visiting scholar Program
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Most of the existing single-component nanostructures cannot provide comprehensive diagnostic information, and their treatment strategies always have to combine other therapeutics as a complementary for effective biomedical application. Here, we adopted a facile approach to design a theranostic nanoflower (NF) with robust efficacy for comprehensive tumor diagnosis and quadruple synergistic cancer therapy. The NF is equipped with a metallic hybrid of several functional elements and flower-like superstructures and thus shows excellent in vitro and in vivo theranostic performance. It shows high X-ray attenuation coefficiency for the Bi element, strong near-infrared (NIR) plasmon absorbance and singlet oxygen (O-1(2)) generation ability for the Mo element, and great photothermal conversion efficiency (54.7%) because of enhanced photoabsorption of the petal structure. Moreover, the NF realizes a very high doxorubicin-loading efficiency (90.0%) and bimodal pH/NIR-responsive drug release, posing a promise as a controlled drug carrier. The NF also shows excellent performance at trimodal magnetic resonance/X-ray computed tomography/photoacoustic imaging for comprehensive tumor diagnosis. To our best knowledge, it is the first time that integrating at least seven functions into one biomedical nanomaterial for well-rounded tumor theranostics has been reported. This all-in-one NF opens a new perspective in developing novel and efficient multifunctional nanotheranostics.
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