Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 47, Pages 44617-44623Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b16288
Keywords
nanohoneycomb; LSPR; SERS; HCC; AFP; AFP-L3
Funding
- National Natural Science Foundation of China [61575080, 61675090, 51901060]
- Project of Jilin Development and Reform Commission [2019C051-3]
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Overexpression of the Lens culinaris agglutininreactive fraction of alpha-fetoprotein (AFP-L3) is an essential biomarker for early diagnosis of hepatocellular carcinoma (HCC). In this study, we designed a new surface-enhanced Raman spectroscopy active chip for the detection of AFP with high sensitivity and excellent repeatability. This chip was composed of a honeycomb gold nanostructure array with strong electromagnetic field coupling due to the special cavity geometric characteristics of the honeycomb structure. The honeycomb structure exhibited extraordinary performance for the specific detection of AFP in the range of 0.003-3 ng/mL and also determined the proportion of AFP-L3 with a high degree of accuracy, which has shown great potential for application in the clinical diagnosis of HCC.
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