Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 43, Pages 39493-39502Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b13470
Keywords
Fenton reaction; doxorubicin; hydrogen peroxide; hydroxyl radicals; computed tomography imaging; chemo-dynamic therapy
Funding
- China Postdoctoral Science Foundation [2018M633141]
- National Natural Science Foundation of China (NSFC) [21671137, 51701054, 31870993]
- Programs for Science and Technology Development of Shenzhen [JSGG20160328151657828]
- Major industrial projects of Shenzhen [s2017001850011]
- Fundamental Research Funds for the Central Universities [WK2070000128]
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Recently, the chemodynamic therapy (CDT) has been widely reported and applied to tumor therapy. However, only low level hydroxyl radicals ((OH)-O-center dot) generated by the endogenous hydrogen peroxide alone are insufficient to kill the cancer cells. To overcome the insufficient therapeutic effect, this study reports a novel CDT based on Fenton catalyst Au@Prussian blue nanocubes (Au@PB NCs), subsequently encapsulated with doxorubicin (Dox). The in vitro and in vivo results indicate that the Dox-Au@PB NCs can take synergistic effects on tumor suppressor by CDT. In addition, Au@PB NCs possess high X-ray computed tomography contrast enhanced efficiency about similar to 27.13 HU.mL.mg(-1). This study highlights a great potential of the Dox-Au@PB NCs for tumor diagnosis and CDT.
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