Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 44, Pages 41051-41061Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b14552
Keywords
cancer-mitochondria-targeted; thermally activated delayed fluorescence (TADF); two-photon activated; fluorescence imaging; photodynamic therapy
Funding
- City University of Hong Kong (CityU Internal Funds for External Grant Schemes Project) [9678157]
- City University of Hong Kong (CityU Applied Research Grant) [9667160]
- Beijing Institute of Technology Research Fund Program for Young Scholars
- National Natural Science Foundation of China [91859123]
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A recent breakthrough in the discovery of thermally activated delayed fluorescence (TADF) emitters characterized by small single-triplet energy offsets (Delta E-ST) offers a wealth of new opportunities to exploit high-performance metal-free photosensitizers. In this report, two intrinsically cancer-mitochondria-targeted TADF emitters-based nanoparticles (TADF NPs) have been developed for two-photon-activated photodynamic therapy (PDT) and fluorescence imaging. The as-prepared TADF NPs integrate the merits of (1) high O-1(2) quantum yield of 52%, (2) sufficient near-infrared light penetration depth due to two-photon activation, and (3) excellent structure-inherent mitochondria-targeting capabilities without extra chemical or physical modifications, inducing remarkable endogenous mitochondria-specific reactive oxygen species production and excellent cancer-cell-killing ability at an ultralow light irradiance. We believe that the development of such intrinsically multifunctional TADF NPs stemming from a single molecule will provide new insights into exploration of novel PDT agents with strong photosensitizing ability for various biomedical applications.
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