Journal
ACS OMEGA
Volume 4, Issue 9, Pages 14021-14031Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.9b01674
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Funding
- NSFC [21632003, 21871116, 21572087]
- key program of the Gansu province [17ZD2GC011]
- 111 program from the MOE of P. R. China
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Herein, we describe the photocatalytic generation of nucleophilic aroyl radicals from simple aroyl chlorides as a universal and efficient cross-coupling strategy for the direct aroylation of heteroarenes. Furthermore, visible light-mediated direct alkylation of heteroarenes has also been achieved using unactivated bromoalkanes as radical precursors. These two strategies feature high functional group tolerance, exclusive regioselectivity for reaction at the more electrophilic position of heteroarenes, easily accessible substrates, and mild reaction conditions. Moreover, mechanism studies of two reactions are carried out to support our hypotheses.
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