Journal
FOODS
Volume 8, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/foods8100440
Keywords
gut microbiota; natural products; diabetes mellitus; complications; mechanisms
Categories
Funding
- Shanghai Basic and Key Program [18JC1410800]
- Technology Innovation Program of Chinese Academy of Agricultural Sciences (ASTIP)
- Shanghai Pujiang Talent Plan [18PJ1404600]
- Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University [Agri-X2017004]
- Key Project of Guangdong Provincial Science and Technology Program [2014B020205002]
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Diabetes mellitus is one of the biggest public health concerns worldwide, which includes type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and other rare forms of diabetes mellitus. Accumulating evidence has revealed that intestinal microbiota is closely associated with the initiation and progression of diabetes mellitus. In addition, various dietary natural products and their bioactive components have exhibited anti-diabetic activity by modulating intestinal microbiota. This review addresses the relationship between gut microbiota and diabetes mellitus, and discusses the effects of natural products on diabetes mellitus and its complications by modulating gut microbiota, with special attention paid to the mechanisms of action. It is hoped that this review paper can be helpful for better understanding of the relationships among natural products, gut microbiota, and diabetes mellitus.
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