Journal
MICROORGANISMS
Volume 7, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms7080271
Keywords
gut microbiota; dysbiosis; diet; extrinsic stressors; intestinal inflammation; IBD
Categories
Funding
- National Research Foundation of Korea [2018M3A9H3025030, 2017M2A2A6A01020874, 2017M3A9F3043849]
- National Research Foundation of Korea [2017M2A2A6A01020874, 2017M3A9F3043849, 2018M3A9H3025030] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The gut microbiota maintains a symbiotic relationship with the host and regulates several important functions including host metabolism, immunity, and intestinal barrier function. Intestinal inflammation and inflammatory bowel disease (IBD) are commonly associated with dysbiosis of the gut microbiota. Alterations in the gut microbiota and associated changes in metabolites as well as disruptions in the intestinal barrier are evidence of the relationship between the gut microbiota and intestinal inflammation. Recent studies have found that many factors may alter the gut microbiota, with the effects of diet being commonly-studied. Extrinsic stressors, including environmental stressors, antibiotic exposure, sleep disturbance, physical activity, and psychological stress, may also play important roles in altering the composition of the gut microbiota. Herein, we discuss the roles of the gut microbiota in intestinal inflammation in relation to diet and other extrinsic stressors.
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