Journal
BIOMOLECULES
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biom9080387
Keywords
stabilin-1; stabilin-2; efferocytosis; phosphatidylserine; fusion
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2017R1A3B1023418]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2017R1A2B4002662]
- KU-KIST Graduate School of Converging Science and Technology Program
- KIST Institutional Program
- National Research Foundation of Korea [2017R1A3B1023418, 2017R1A2B4002662] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) and cell fusion, and their ligand-recognition and signaling pathways.
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