Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2019.00185
Keywords
lipophagy; lipid droplet; fatty acids; aging; fatty liver disease; fibrosis; cancer; obesity
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Funding
- Hellenic Foundation for Research and Innovation (HFRI) [1586]
- European Research Council [ERC - GA695190 - MANNA]
- Operational Programme Competitiveness, Entrepreneurship and Innovation (NSRF 2014-2020) - European Union (European Regional Development Fund) project Advanced Research Activities in Biomedical and Agro alimentary Technologies [MIS 5002469]
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The term lipophagy is used to describe the autophagic degradation of lipid droplets, the main lipid storage organelles of eukaryotic cells. Ever since its discovery in 2009, lipophagy has emerged as a significant component of lipid metabolism with important implications for organismal health. This review aims to provide a brief summary of our current knowledge on the mechanisms that are responsible for regulating lipophagy and the impact the process has under physiological and pathological conditions.
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