Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Volume 1859, Issue 6, Pages 825-831Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2016.04.006
Keywords
Transcription factor; OCT-1; OCA-B; CTCF; Cohesin; Gene regulation; Chromosomal association; CD4 T cell differentiation
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Funding
- Yale Cancer Center
- National Research Foundation of Korea (NRF) - Korean government [NRF-2014R1A2A1A11052545]
- Howard Hughes Medical Institute
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The understanding of CD4 T cell differentiation gives important insights into the control of immune responses against various pathogens and in autoimmune diseases. Naive CD4 T cells become effector T cells in response to antigen stimulation in combination with various environmental cytokine stimuli. Several transcription factors and cis-regulatory regions have been identified to regulate epigenetic processes on chromatin, to allow the production of proper effector cytokines during CD4 T cell differentiation. OCT-1 (Pou2f1) is well known as a widely expressed transcription factor in most tissues and cells. Although the importance of OCT-1 has been emphasized during development and differentiation, its detailed molecular underpinning and precise role are poorly understood. Recently, a series of studies have reported that OCT-1 plays a critical role in CD4 T cells through regulating gene expression during differentiation and mediating long-range chromosomal interactions. In this review, we will describe the role of OCT-1 in CD4 T cell differentiation and discuss how this factor orchestrates the fate and function of CD4 effector T cells. (C) 2016 Published by Elsevier B.V.
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