Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1858, Issue 3, Pages 593-606Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2015.09.023
Keywords
Nanopore; Hemolysin; Pore forming toxin; DNA sequencing; Force spectroscopy; Temperature-jump spectroscopy
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Funding
- NIH NHGRI [R01HG007415]
- European Molecular Biology Organization post-doctoral fellowship
- Shenzhen Dedicated Funding of Strategic Emerging Industry Development Program [JCYJ20130408173226864]
- China Postdoctoral Science Foundation [2014M560670]
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Proteinaceous nanometer-scale pores are ubiquitous in biology. The canonical ionic channels (e.g., those that transport Na+, K+, Ca2+, and Cl- across cell membranes) play key roles in many cellular processes, including nerve and muscle activity. Another class of channels includes bacterial pore-forming toxins, which disrupt cell function, and can lead to cell death. We describe here the recent development of these toxins for a wide range of biological sensing applications. This article is part of a Special Issue entitled: Pore-Forming Toxins edited by Mauro Dalla Serra and Franco Gambale. Published by Elsevier B.V.
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