Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1858, Issue 5, Pages 1061-1069Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2015.12.015
Keywords
Biofilms; Synthetic peptides; Persistent infections; Synergy; Antibiotic resistance; Biomaterials
Categories
Funding
- Fundacion la Caixa
- Fundacion Canada (Spain)
- Fundacion Ramon Areces (Spain)
- CNPq
- CAPES
- FUNDECT
- FAPDF
Ask authors/readers for more resources
Bacteria predominantly exist as multicellular aggregates known as biofilms that are associated with at least two thirds of all infections and exhibit increased adaptive resistance to conventional antibiotic therapies. Therefore, biofilms are major contributors to the global health problem of antibiotic resistance, and novel approaches to counter them are urgently needed. Small molecules of the innate immune system called host defense peptides (HDPs) have emerged as promising templates for the design of potent, broad-spectrum antibiofilm agents. Here, we review recent developments in the new field of synthetic antibiofilm peptides, including mechanistic insights, synergistic interactions with available antibiotics, and their potential as novel antimicrobials against persistent infections caused by biofilms. This article is part of a Special Issue entitled: Antimicrobial peptides edited by Karl Lohner and Kai Hilpert. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available