Journal
FOOD SCIENCE & NUTRITION
Volume 7, Issue 10, Pages 3216-3223Publisher
WILEY
DOI: 10.1002/fsn3.1176
Keywords
adlay bran oil; anti-hyperpigmentation; melanin; nanoemulsion; tyrosinase; zebrafish
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Funding
- Ministry of Science and Technology, Republic of China [MOST 107-2320-B-002-003MY3, MOST 105-2320-B-002-004-]
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The efficacy of oily components is often difficult to evaluate due to their incompatibility with most models. Here, we emulsified adlay bran oil (ABO), processed it to a nanoscale, and investigated its anti-hyperpigmentation efficacy, assessed for its inhibitory effects against tyrosinase activity and melanin production, in an in vitro system (mouse melanoma B16F10 cells) and an in vivo system (zebrafish embryos). ABO induced dose-dependent reductions in tyrosinase activity and melanin production in both the melanoma cells and zebrafish, without affecting viability. The efficacy of ABO was strongly influenced by emulsion particle size in the zebrafish but not in the cells. These results indicate that ABO has potential as a tyrosinase inhibitor and anti-hyperpigmentation agent and that the emulsion system is an effective method for delivering the bioactive components of ABO to living systems that could be utilized for other oily components.
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