Journal
NPJ MICROGRAVITY
Volume 5, Issue -, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41526-019-0081-4
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Funding
- postdoctoral NIH T32 Training Grant in Hematopoiesis [T32 DK007519]
- postdoctoral NIH T32 Training Grant in Musculoskeletal Biology [T32 AR065971]
- Center for Research and Learning RISE Scholarship, Indiana University Purdue University Indianapolis
- Life and Health Sciences Internship Program at Indiana University-Purdue University Indianapolis
- Department of Orthopaedic Surgery, Indiana University School of Medicine
- Orthopaedic Trauma Association
- Ralph W. and Grace M. Showalter Research Trust Fund
- NIH NIAMS [R01 AR060863]
- Center for the Advancement of Sciences in Space (CASIS) [GA-2015-217]
- US Army Medical Research and Materiel Command
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Gravity has an important role in both the development and maintenance of bone mass. This is most evident in the rapid and intense bone loss observed in both humans and animals exposed to extended periods of microgravity in spaceflight. Here, cohabitating 9-week-old male C57BU6 mice resided in spaceflight for similar to 4 weeks. A skeletal survey of these mice was compared to both habitat matched ground controls to determine the effects of microgravity and baseline samples in order to determine the effects of skeletal maturation on the resulting phenotype. We hypothesized that weight-bearing bones would experience an accelerated loss of bone mass compared to non-weight-bearing bones, and that spaceflight would also inhibit skeletal maturation in male mice. As expected, spaceflight had major negative effects on trabecular bone mass of the following weight-bearing bones: femur, tibia, and vertebrae. Interestingly, as opposed to the bone loss traditionally characterized for most weight-bearing skeletal compartments, the effects of spaceflight on the ribs and sternum resembled a failure to accumulate bone mass. Our study further adds to the insight that gravity has site-specific influences on the skeleton.
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