4.7 Article

Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin

Journal

PHARMACEUTICS
Volume 11, Issue 9, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics11090430

Keywords

curcumin; mesoporous silica nanoparticles; functional; delivery; cancer

Funding

  1. National Natural Science Foundation of China [21476212]
  2. Science and Technology department of Zhejiang Province [2018C02038]
  3. Foundation of Bureau of Science and Technology of Zhoushan [2019C21023]

Ask authors/readers for more resources

Nano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug delivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues. Mesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have large specific surface areas, adjustable pore sizes, easily modifiable surfaces, and good biocompatibility. In this work, polyethyleneimine (PEI) grafted MSN were modified with folic acid (FA) as an active target molecule using chemical methods. The product was characterized by SEM, TEM, Zetasizer nano, FTIR, and an N-2 adsorption and desorption test. MSN-PEI-FA are porous nano particles with an average particle size of approximately 100 nm. In addition, the loading rate and release behavior of MSN-PEI-FA were studied with curcumin as a model drug. The results show that when loading curcumin to MSN-PEI-FA at 7 mg and 0.1 g, respectively, the encapsulation efficiency was 90% and the cumulative release rate reached more than 50% within 120 h at pH = 5. This drug delivery system is suitable for loading fat-soluble antineoplastic drugs for sustained release and pH sensitive delivery.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available