Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
Volume 1857, Issue 7, Pages 863-871Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2015.11.004
Keywords
NADH:quinone oxidoreductase; Proton pumping; Hydrogen peroxide; Superoxide; Bacterial plasma membranes; Mitochondria
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Funding
- Russian Foundation for Fundamental Research Grant [14-04-00279, 15-04-02957]
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Kinetic characteristics of the proton-pumping NADH:quinone reductases (respiratory complexes I) are reviewed. Unsolved problems of the redox-linked proton translocation activities are outlined. The parameters of complex I-mediated superoxide/hydrogen peroxide generation are summarized, and the physiological significance of mitochondrial ROS production is discussed. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. (C) 2015 Elsevier B.V. All rights reserved.
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