Journal
CELLS
Volume 8, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/cells8091058
Keywords
multiple sclerosis; extracellular vesicles; TLR3; TLR4; innate immunity
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Funding
- Conrad Hilton Foundation
- John F. Kurtzke Clinician Scientist development award from the American Academy of Neurology
- National MS Society
- Race to Erase MS
- Intramural Research Program of the National Institute on Aging, NIH
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Extracellular vesicles (EVs) are involved in inter-cellular communication and their cargo may provide prognostic/diagnostic biomarkers. To discover EV-associated biomarkers for Multiple Sclerosis (MS), we used an immune marker array to identify surface proteins on circulating EVs that differ between MS patients and controls (n = 3 each). We identified toll-like receptor-3 (TLR3) as a potential target for further validation. We utilized prospectively collected serum from relapsing-remitting MS patients (n = 18) and controls (n = 16) and confirmed lower concentration of TLR3 and higher concentration of mechanistically related TLR4 in MS EVs compared to controls. Future studies may further evaluate the utility of EV-associated TLRs as MS biomarkers and uncover their mechanistic significance.
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