Journal
CELLS
Volume 8, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cells8080890
Keywords
carbohydrate metabolism; ADP-ribosylation; ARTD; PARP; NAD(+); NR; NMN; NAM
Categories
Funding
- Kanton of Zurich
- Swiss National Science Foundation [310030_157019, 31003A_176177]
- Swiss National Science Foundation (SNF) [31003A_176177, 310030_157019] Funding Source: Swiss National Science Foundation (SNF)
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Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD(+), a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD(+) as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD(+)-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD(+) biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments.
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